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Estimated GFR (eGFR) was calculated according to gender, age and the concentration of serum Cr according the Japanese equation Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) 62

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Hallmarks of aging: An expanding universe Cell , 2023

The images underwent downsizing, cutting, autocolor balancing, and autobrightness adjustments via Adobe Photoshop (RRID: SCR_014199) to improve the figure and data presentation clarity